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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Antimalarial Natural Products

Antimalarial Natural Products

Kinghorn, A. Douglas
Falk, Heinz
Gibbons, Simon

Paperback

Series: Progress in the Chemistry of Organic Natural Products, Book 117

Medical ReferenceChemistry

ISBN10: 303089875X
ISBN13: 9783030898755
Publisher: Springer Nature
Published: Jan 5 2023
Pages: 106
Weight: 0.39
Height: 0.25 Width: 6.14 Depth: 9.21
Language: English
This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

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