Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Chimeric Vaccine Design Against Melioidosis via Subtractive Proteomics

Chimeric Vaccine Design Against Melioidosis via Subtractive Proteomics

Ahmad Khan, Mohammad Kalim
Akhtar, Salman
Maurya, Shalini

Paperback

Biology

ISBN10: 6208417252
ISBN13: 9786208417253
Publisher: LAP Lambert Academic Publishing
Published: Dec 19 2024
Pages: 120
Weight: 0.41
Height: 0.28 Width: 6.00 Depth: 9.00
Language: English
Subtractive proteomics and reverse vaccinology were employed to design a chimeric multi-epitope vaccine against melioidosis, a severe infectious disease caused by the multidrug-resistant bacterium, Burkholderia pseudomallei. From 21 non-redundant pathogen proteomes, four proteins were selected as vaccine candidates based on essentiality, virulence, non-homology to humans, structural availability, subcellular localization, and antigenicity. The major histocompatibility complex class I, II, and B-cell epitopes were predicted and evaluated for immunogenicity, solubility, allergenicity, and hydrophilicity. A chimeric vaccine was constructed using the epitopes, adjuvants, linkers, and PADRE sequences. Docking and molecular dynamics simulations confirmed interactions between HLA alleles and TLR4, indicating the potential to elicit an immune response, demonstrating the utility of computational tools in developing vaccines against B. pseudomallei.

Also from

Ahmad Khan, Mohammad Kalim

View All

Also in

Biology

View All