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Les péchés des gènes
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ISBN10: 6208097576
ISBN13: 9786208097578
Publisher: Editions Notre Savoir
Published: Sep 18 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786208097578
Publisher: Editions Notre Savoir
Published: Sep 18 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: French
Aujourd'hui, le cancer du sein est le cancer le plus fréquent chez les femmes et il est responsable de 25 % de tous les cancers chez les femmes. La télomérase est une cible thérapeutique anticancéreuse appropriée car elle est présente dans plus de 90 % des cancers humains, dont plus de 95 % des cancers du sein, alors qu'elle n'est pas détectable dans la plupart des cellules somatiques. La protéine hTERT est un composant du complexe télomérase à vitesse limitée, de sorte que l'expression du gène hTERT à l'intérieur des cellules est essentielle pour l'activation de la télomérase. Les miARN sont un ensemble de petits ARN non codants d'une longueur de 25 à 19 nucléotides qui jouent un rôle clé en tant que régulateurs de l'expression des gènes.Une certaine susceptibilité génétique peut jouer un rôle mineur dans la plupart des cas. Les femmes dont la mère a été diagnostiquée avant 50 ans ont un risque accru de 1,7 et celles dont la mère a été diagnostiquée à l'âge de 50 ans ou après ont un risque accru de 1,4. Chez celles qui n'ont aucune, une ou deux parentes atteintes, le risque de cancer du sein avant l'âge de 80 ans est de 7,8 %, 13,3 % et 21,1 %, avec une mortalité ultérieure due à la maladie de 2,3 %, 4,2 % et 7,6 % respectivement.
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