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Modèles de rongeurs pour les troubles du spectre autistique: forces et limites
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ISBN10: 6208599970
ISBN13: 9786208599973
Publisher: Editions Notre Savoir
Published: Jan 28 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786208599973
Publisher: Editions Notre Savoir
Published: Jan 28 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
Les troubles du spectre autistique (TSA) sont une maladie psychiatrique qui résulte d'une interaction complexe entre des facteurs génétiques et environnementaux. Des modèles animaux ont été utilisés pour mieux comprendre l'étiologie de ce trouble, pour trouver un étalon-or permettant de poser un diagnostic et pour rechercher des traitements. Dans cet ouvrage, les modèles de rongeurs pour les TSA font l'objet d'un examen critique en ce qui concerne leur utilisation pour imiter la complexité de la biologie du développement de la maladie. Leur validité est évaluée, ainsi que les tests de phénotypage comportemental appliqués. Les orientations futures vont dans le sens d'une approche multi-modèle, dans laquelle l'accent est mis sur le corps en tant que système fonctionnel unique. Les modèles animaux sont toujours un compromis entre la reproduction de la complexité du trouble réel et la conception d'expériences pratiques. Toutefois, ces expériences doivent être conçues de manière à ce que l'animal soit le moins possible limité dans l'exécution de son comportement naturel. En combinant les connaissances, nous réduisons l'entonnoir vers non seulement un modèle de référence, mais aussi une stratégie de phénotypage comportemental de référence, augmentant ainsi la capacité translationnelle du modèle animal.
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