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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
G Protein-Coupled Receptors: Immobilization and Applications in Drug Discovery

G Protein-Coupled Receptors: Immobilization and Applications in Drug Discovery

Zhao, Xinfeng
Li, Qian
Wang, Jing

Paperback

Series: Springerbriefs in Molecular Science

Chemistry

ISBN10: 9819900778
ISBN13: 9789819900770
Publisher: Springer Nature
Published: Feb 21 2023
Pages: 91
Weight: 0.35
Height: 0.22 Width: 6.14 Depth: 9.21
Language: English
This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the post-structural biology era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.

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