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Depression und Suizid
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ISBN10: 6209509916
ISBN13: 9786209509919
Publisher: Verlag Unser Wissen
Published: Jan 26 2026
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786209509919
Publisher: Verlag Unser Wissen
Published: Jan 26 2026
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: German
Die Major Depression (MDD) ist eine der am schwierigsten zu untersuchenden psychiatrischen Erkrankungen. Es handelt sich um eine polygene Erkrankung mit einer Lebenszeitprävalenz von 10-15 %, wobei Frauen aus unbekannten Gründen doppelt so häufig betroffen sind wie Männer. Die hohe Lebenszeitprävalenz dieser nicht infektiösen, aber stark beeinträchtigenden Erkrankung erfordert Fortschritte auf diesem Gebiet, damit bessere Therapeutika entwickelt werden können, um Patienten wirksamer zu behandeln. Genomweite Assoziationsstudien zur Major Depression haben bislang noch keine signifikanten Ergebnisse geliefert. Dies liegt wahrscheinlich daran, dass die Auswirkungen einzelner Loci gering sind und/oder dass die Heterogenität der Erkrankung hoch ist. Die Beteiligung nicht-genetischer Faktoren wie Umweltvariablen ist ein weiterer komplizierender Faktor. Infolgedessen ist die Entschlüsselung der genetischen Architektur schwierig. Obwohl sowohl Gene als auch die Umwelt Faktoren für die Entwicklung einer MDD sind, konzentriert sich dieses Buch auf die Genetik der Erkrankung. Es besteht ein dringender Bedarf, die genetischen Grundlagen der MDD zu verstehen, und es ist unser Ziel, dies mithilfe von Next-Generation-Sequencing zu erreichen, um die genomischen Varianten und dysregulierten Gene zu entdecken, die bei ihrer Entwicklung eine Rolle spielen.
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