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МикроРНК-27а* и естественн
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ISBN10: 620768236X
ISBN13: 9786207682362
Publisher: Sciencia Scripts
Published: Jun 21 2024
Pages: 88
Weight: 0.31
Height: 0.21 Width: 6.00 Depth: 9.00
Language: Russian
ISBN13: 9786207682362
Publisher: Sciencia Scripts
Published: Jun 21 2024
Pages: 88
Weight: 0.31
Height: 0.21 Width: 6.00 Depth: 9.00
Language: Russian
Системная красная волчанка (СКВ) - это хроническое аутоиммунное заболевание, характеризующееся нарушением выработки аутореактивных антител, что приводит к разнообразным клиническим проявлениям. Естественные клетки-киллеры (NK), 3-я по величине популяция лимфоцитов, вносят значительный вклад в патогенез SLE. МиРНК - малые некодирующие молекулы РНК, которые играют важную роль в регуляции экспрессии генов NK через посттранскрипционные механизмы; однако при SLE это еще не исследовалось. Таким образом, целью данной работы стало изучение экспрессии миРНК, которые потенциально могут быть направлены на важный рецептор активации NK, NKG2D, в мононуклеарных клетках периферической крови (МКПК) и NK-клетках пациентов с SLE. Наблюдаемые аномалии в экспрессии триады miR-27a*, NKG2D и ULBP2 считаются жизненно важными аспектами в расшифровке нарушенной цитотоксичности, характерной для NK-клеток у пациентов с SLE. Более того, мимикрирование miR-27a* способно усилить экспрессию NKG2D, что может стать основой для терапевтических вмешательств, напра
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