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I Domains in Integrins

I Domains in Integrins

Hardcover

Series: Molecular Biology Intelligence Unit

BiologyChemistry

ISBN10: 0306478366
ISBN13: 9780306478369
Publisher: Springer Nature
Published: Jul 31 2003
Pages: 186
Weight: 1.13
Height: 0.75 Width: 6.24 Depth: 9.52
Language: English
In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.

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