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Attività non citotossica del veleno di B. jaracussu
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ISBN10: 6206835537
ISBN13: 9786206835530
Publisher: Edizioni Sapienza
Published: May 8 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786206835530
Publisher: Edizioni Sapienza
Published: May 8 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: Italian
I veleni degli ofidi sono risorse biologiche di importante valore farmacologico. Oltre al ridotto numero di farmaci antivirali, numerosi agenti patogeni sviluppano meccanismi per sfuggire all'azione dei farmaci, con conseguente aumento del tasso di resistenza. È stato dimostrato che le biomolecole contenute nei veleni degli ofidi hanno un elevato valore terapeutico e potrebbero essere utilizzate come agenti antimicrobici. Lo scopo di questo lavoro è valutare l'attività non citotossica del veleno grezzo isolato da Bothrops jararacussu nelle cellule mononucleari del sangue periferico. In questo studio sono state separate le cellule mononucleate di donatori sani. Dopo aver attivato le cellule con fitoemoagglutinina e interleuchina-2, sono state aggiunte diverse concentrazioni di veleno per valutarne l'attività non citotossica. Questo studio apre la strada a nuove ricerche volte a identificare le attività antimicrobiche dei veleni grezzi e delle loro frazioni.
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