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Przejście nablonkowo-mezenchymalne
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ISBN10: 6209360106
ISBN13: 9786209360107
Publisher: Wydawnictwo Nasza Wiedza
Published: Nov 26 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209360107
Publisher: Wydawnictwo Nasza Wiedza
Published: Nov 26 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Polish
Przejście nablonkowo-mezenchymalne (EMT) stanowi fundamentalny proces biologiczny, w którym komórki nablonkowe tracą swoją charakterystyczną polaryzację, adhezję międzykomórkową i zorganizowaną architekturę, nabywając fenotyp mezenchymalny charakteryzujący się zwiększoną ruchliwością, inwazyjnością i odpornością na apoptozę. To odwracalne zdarzenie przeprogramowania komórkowego odgrywa kluczową rolę w rozwoju embrionalnym, regeneracji tkanek, zwlóknieniu i progresji nowotworów. W ciągu ostatnich kilku dekad EMT stalo się kluczowym paradygmatem w biologii komórkowej i patologii, lącząc procesy rozwojowe i mechanizmy chorobowe poprzez regulację plastyczności komórkowej. Zrozumienie dynamiki molekularnej, komórkowej i sygnalowej EMT stalo się zatem niezbędne do zrozumienia szerokiego spektrum zjawisk fizjologicznych i patologicznych. W embriogenezie EMT reguluje kluczowe zdarzenia morfogenetyczne, takie jak gastrulacja, tworzenie grzebienia nerwowego i rozwój narządów. Przejściowa i ściśle regulowana przemiana komórek nablonkowych w migrujące komórki mezenchymalne ulatwia przebudowę tkanek i tworzenie wzorów przestrzennych niezbędnych do formowania zlożonych struktur wielokomórkowych.
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