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Wirus brodawczaka bydla: co wiemy i co powinniśmy wiedziec
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ISBN10: 6202202785
ISBN13: 9786202202787
Publisher: Wydawnictwo Nasza Wiedza
Published: Sep 13 2025
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786202202787
Publisher: Wydawnictwo Nasza Wiedza
Published: Sep 13 2025
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Polish
Wirus brodawczaka bydla (BPV) jest czynnikiem etiologicznym brodawczaka bydla, choroby zakaźnej powodującej znaczne straty ekonomiczne w hodowli bydla, charakteryzującej się obecnością brodawczaków, które ustępują samoistnie. Jednak brodawczaki mogą utrzymywac się i przeksztalcac się w nowotwory zlośliwe. W niniejszym badaniu stwierdzono obecnośc BPV-2 w ponad 80% próbek. Analiza histopatologiczna ujawnila istotne zmiany, w tym obecnośc transformowanych fibroblastów, co potwierdza rolę wirusa w powstawaniu nowotworów zlośliwych. Wynik ten sugeruje również drogę zakażenia poprzez krew. Badanie immunohistochemiczne ujawnilo obecnośc bialka L1 zarówno w naskórku, jak i skórze wlaściwej, co sugeruje produktywne zakażenie w innych miejscach. Zaobserwowano wyraźne znakowanie onkoproteiny E7 we wszystkich warstwach nablonka i zrębu, co świadczy o aktywności wirusa w fibroblastach. CA wykazalo, że wszystkie gatunki BPV mają podobne dzialanie klastogenne. Wyniki potwierdzają onkogenną rolę BPV w tworzeniu mikrośrodowiska sprzyjającego transformacji nowotworowej. Cząsteczki BPV zostaly pomyślnie wyizolowane z próbek, w których zidentyfikowano BPV-2, przy użyciu nowatorskiej techniki izolacji wirusa brodawczaka.
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