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Latcripin-7A, derivado de Lentinula edodes C91-3, induz a apoptose
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ISBN10: 6206002691
ISBN13: 9786206002697
Publisher: Edicoes Nosso Conhecimento
Published: May 17 2023
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786206002697
Publisher: Edicoes Nosso Conhecimento
Published: May 17 2023
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Portuguese
O cancro gástrico (CG) é considerado o terceiro cancro mais letal entre os cancros, seguido do cancro do pulmão e do cancro colorretal. Os casos de CG estão a aumentar gradualmente, com uma taxa de escalada de 5,7% aproximadamente documentada apenas em 2019. De acordo com o registo de 2015, a maioria dos novos casos, quase 50% dos doentes, foi diagnosticada na América do Sul e Central, na Europa Oriental e na Ásia Oriental. Em comparação, a América do Norte, a África, o Sul da Ásia, a Austrália e a Nova Zelândia registaram um número significativamente menor de casos. Os cogumelos têm uma longa história de utilização como medicamento e fonte de alimentação, que se acredita ser uma fonte de alimentação deliciosa e saudável. Os Lentinula edodes, também conhecidos como cogumelos shiitake, têm um potencial de actividade antitumoral. Estudos recentes mostraram que o Lentinula edodes tem efeitos potenciais e significativos na apoptose celular e a sua fonte bem intencionada para diminuir as reacções antagónicas da quimioterapia. Os péptidos obtidos a partir de Lentinula edodes (LP-1, LP-13) proporcionaram resultados substanciais em vários tipos de cancro, aumentando a apoptose. O LP-1 também inibe a migração e a invasão das células do CG, travando o crescimento celular na fase S através das vias da fosfatidilinositol-3-quinase (PI3K)/Akt.
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