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Selenio, genes codificadores de selenoproteÃnas e cancros dependentes de CHEK2
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ISBN10: 6209673295
ISBN13: 9786209673290
Publisher: Edicoes Nosso Conhecimento
Published: Feb 26 2026
Pages: 124
Weight: 0.39
Height: 0.29 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209673290
Publisher: Edicoes Nosso Conhecimento
Published: Feb 26 2026
Pages: 124
Weight: 0.39
Height: 0.29 Width: 6.00 Depth: 9.00
Language: Portuguese
No nosso estudo, investigámos se a concentração de selénio pode ser utilizada como um marcador valioso para a deteção precoce de cancros num grupo de indivÃduos com mutações CHEK2 e em pacientes não selecionados. Encontrámos uma associação muito significativa entre uma concentração mais elevada de selénio e uma menor probabilidade de deteção de cancro nos grupos testados. Esta observação é particularmente valiosa para indivÃduos portadores da mutação CHEK2, que apresentam um risco aumentado de cancro. Também encontrámos algumas evidências da associação de rs1139793 em TXNDR2 e rs5845 em SEP15 com o risco de cancro em portadores de CHEK2, o que pode ser útil para a determinação da avaliação do risco pessoal. Em resumo, a concentração sérica de selénio parece ser um marcador valioso para a seleção de indivÃduos para exames de vigilância, como tomografia computadorizada ou colonoscopia, para a deteção dos estágios mais precoces dos cancros brônquicos e colorretais. Também deve ser considerada no programa de vigilância de indivÃduos com portadores da mutação CHEK2 detectada. São necessárias análises adicionais para elucidar o papel das variações nos genes da selenoproteÃna no risco de cancro em portadores de CHEK2.
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