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    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Regulation of Membrane Na+-K+ Atpase

Regulation of Membrane Na+-K+ Atpase

Chakraborti, Sajal
Dhalla, Naranjan S.

Hardcover

Series: Advances in Biochemistry in Health and Disease, Book 15

BiologyChemistryPhysics

ISBN10: 3319247484
ISBN13: 9783319247489
Publisher: Springer Nature
Published: Dec 22 2015
Pages: 436
Weight: 1.77
Height: 1.00 Width: 6.14 Depth: 9.21
Language: English

Na+-K+ ATPase or Na-pump ATPase, a member of P-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra

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