Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Synthesis and Biological Investigations of Oxa/Aza Heterocyclics

Synthesis and Biological Investigations of Oxa/Aza Heterocyclics

Sanjeeva, Pagidirai
Subba Rao, Bandi
Venkata Ramana, Peddakotla

Paperback

Chemistry

ISBN10: 6209088732
ISBN13: 9786209088735
Publisher: LAP Lambert Academic Publishing
Published: Oct 27 2025
Pages: 192
Weight: 0.58
Height: 0.44 Width: 6.00 Depth: 9.00
Language: English
The development of heterocycles as scaffolds containing a high degree of diversity has become a leading focus in modern drug discovery. In this research program the derivatives of various diverse classes of heterocycles e.g.oxadiazole, triazole and pyrazole were developed. The modification and optimization of reaction conditions, characterization of the structure of newly synthesized compounds and a study of their biological activity would definitely contribute to update the existing knowledge in the field of heterocyclic chemistry. The part of the present work gives an overview of methods of the synthesis of substituted triazoles, oxadiazoles and pyrazoles. It will explain how different conditions and structure of substrates can influence the direction for reactions.A brief review of literature has been presented along with the objectives of the work. The anti-bacterial studies revealed that majority of the tested compounds exhibited moderate to good antibacterial activity. The docking study revealed the binding orientation of compounds in the DNA GyrB and Asp kinase of antituberculosis binding pocket surrounding the active site, which resulted in inhibition of enzyme activity.

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