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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Ultracentrifugal analysis of biomolecular interaction processes

Ultracentrifugal analysis of biomolecular interaction processes

Decker, Christina

Paperback

Chemistry

ISBN10: 6208906369
ISBN13: 9786208906368
Publisher: Our Knowledge Publishing
Published: May 29 2025
Pages: 112
Weight: 0.35
Height: 0.27 Width: 6.00 Depth: 9.00
Language: English
As an absolute method in solution, analytical ultracentrifugation (AUC) enables the quantitative analysis of macromolecules based on their hydrodynamic separation in an applied centrifugal field. These fundamental properties of AUC allow extensive analysis of macromolecules in their native state under biologically relevant conditions and can provide information on their sedimentation coefficients, mass, shape, diffusion coefficients and density. Using gold nanoparticles and the two binding proteins amyloid-beta 42 and BSA, a generally valid procedure for an AUZ-based characterization of ligand-modified nanoparticles is explained with a subsequent quantification of their surface modification by the ligands. Based on the physical-technical fundamentals of AUC, the use of absorption and fluorescence detection systems and the work in the fields of protein and nanoparticle analysis, the broad application possibilities of analytical ultracentrifugation are illustrated and explained.

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