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Drug-Induced Kidney Injury: Pathophysiology and Clinical Aspects

Drug-Induced Kidney Injury: Pathophysiology and Clinical Aspects

Paperback

Business General

ISBN10: 6208452430
ISBN13: 9786208452438
Publisher: LAP Lambert Academic Publishing
Published: Jun 19 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: English
The kidneys, vital for filtering the body's waste, are highly vulnerable to drug-induced nephrotoxicity, a leading cause of acute kidney injury (AKI) in hospitalized patients, with up to 60% of cases linked to medications such as antibiotics, chemotherapy, and analgesics. This book addresses the urgent need to balance pharmacological innovation with kidney protection. Recent advances have deepened understanding of nephrotoxicity, revealing complex molecular, genetic, and biomarker-driven mechanisms, while multi-drug regimens and aging populations add further complexity. Designed for clinicians, researchers, and trainees, the text covers epidemiology, pathophysiology, high-risk drug classes, diagnostic tools (including biomarkers like KIM-1 and cystatin C), and prevention strategies, illustrated by case studies and the 6R's of Nephrotoxicity framework. Collaborative and interdisciplinary, it emphasizes stewardship, vigilant monitoring, and patient education. The book also explores future directions, such as genomic risk prediction, AI-driven pharmacovigilance, and equitable kidney care, aiming to inspire a commitment to safe prescribing and renal stewardship.

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Business General