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Activité Antiagrégante des Extraits de Cinq Plantes Médicinales
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ISBN10: 6209109403
ISBN13: 9786209109409
Publisher: Editions Universitaires Europeennes
Published: Oct 20 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209109409
Publisher: Editions Universitaires Europeennes
Published: Oct 20 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: French
Les plaquettes sanguines (ou thrombocytes) jouent un rôle central dans les mécanismes de l'hémostase et le maintien de l'intégrité vasculaire. Cependant, leur activation excessive peut contribuer au développement de maladies cardio-vasculaires, comme la thrombose et l'athérosclérose. L'objectif de ce travail est d'examiner in vitro l'effet antiagrégant des extraits de cinq plantes médicinales marocaines: Arbutus unedo, Urtica dioica, Petroselinum crispum, Cistus ladaniferus et Equisetum arvense chez le rat. Les résultats obtenus montrent que les extraits testés inhibent l'agrégation plaquettaire de manière dose-dépendante. A 10 mg/mL, le degré d'inhibition de l'agrégation varie entre 28,1 % et 78,1 % pour la thrombine, et entre 41,5 % et 82,24 % pour l'ADP. Les valeurs calculées d'CI50 pour les extraits testés varient entre 5,68 et 15,5 mg/mL. En outre, les plantes testées réduisent la vitesse d'agrégation plaquettaire de manière significative. Ces effets seraient liés à la présence dans les extraits des plantes testées de principes actifs ayant une action antiagrégante, et qui pourraient être bénéfiques pour le traitement de certains pathologies cardiovasculaires comme l'athérosclérose et les thromboses. D'autres travaux sont prévus pour identifier les composés actifs responsables de l'effet anti-agrégant, et élucider leur mécanisme d'action.
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