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La curcumine a inhibé l'endothéline-1 cardiaque chez les rats traités au lindane
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ISBN10: 6209129021
ISBN13: 9786209129025
Publisher: Editions Notre Savoir
Published: Oct 15 2025
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209129025
Publisher: Editions Notre Savoir
Published: Oct 15 2025
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: French
Le lindane (gamma hexachlorohexane) est le plus toxique de tous les isomères de l'hexachlorohexane. Il possède de puissantes propriétés insecticides et est utilisé pour lutter contre les insectes nuisibles dans les cultures et les habitations. L'une des principales voies d'exposition humaine est la contamination alimentaire, ses résidus ayant été détectés dans l'eau, le lait, l'huile de cuisson et le poisson. Dans le foie, le lindane agirait en interférant avec la capacité oxydative hépatique et le métabolisme du glutathion. Le premier objectif de cette étude était d'explorer l'effet histopathologique du lindane sur le coeur et le rôle de la CK et de l'ET-1 dans la toxicité cardiaque chez les rats mâles. Le deuxième objectif était de tester l'hypothèse selon laquelle la curcumine aurait des rôles cardioprotecteurs et antioxydants contre ces effets toxiques.
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