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La L-carnitine et l'ADN
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ISBN10: 6209159613
ISBN13: 9786209159619
Publisher: Editions Notre Savoir
Published: Oct 22 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209159619
Publisher: Editions Notre Savoir
Published: Oct 22 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: French
La L-carnitine (LC) est une amine quaternaire qui joue un rôle fondamental dans la production d'énergie par les cellules, car elle intervient dans les réactions de transfert des acides gras libres à longue chaîne du cytosol vers les mitochondries, facilitant ainsi leur oxydation et la production d'adénosine triphosphate (ATP). Afin d'évaluer les activités antioxydantes, génotoxiques et antigénotoxiques de la LC chez les souris, des souris mâles ont été utilisées dans l'expérience et réparties en 4 groupes de 7 animaux chacun. La LC a été administrée par voie intrapéritonéale et la lipoperoxydation (LPO) a été évaluée par la méthode TBARS, tandis que l'activité antioxydante a été évaluée à l'aide des enzymes superoxyde dismutase et catalase. À des doses plus faibles de L-carnitine, on a observé une augmentation de la SOD et de la CAT, tandis qu'à des doses plus élevées, on a observé une diminution de ces mêmes enzymes, suggérant une peroxydation lipidique d'après les résultats du test TBARS. La LC à toutes les doses utilisées dans le test des étoiles comètes dans le sang et le foie n'a pas présenté d'activité génotoxique, mais a réduit les dommages oxydatifs générés par le peroxyde d'hydrogène, suggérant une action antigénotoxique. Ce livre s'adresse donc aux biologistes, aux généticiens et à tous ceux qui utilisent le test des étoiles comètes pour leurs analyses.
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