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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
L-Carnitine and DNA

L-Carnitine and DNA

Luz, Emmanuel Wassermann Moraes
Picada, Jaqueline N.
Marroni, Norma A. P.

Paperback

Genetics

ISBN10: 6209141706
ISBN13: 9786209141706
Publisher: Our Knowledge Publishing
Published: Oct 22 2025
Pages: 76
Weight: 0.25
Height: 0.18 Width: 6.00 Depth: 9.00
Language: English
L-carnitine (LC) is a quaternary amine that plays a fundamental role in cellular energy production, as it acts in the transfer of long-chain free fatty acids from the cytosol to the mitochondria, facilitating their oxidation and the production of adenosine triphosphate (ATP). In order to evaluate the antioxidant, genotoxic, and antigenotoxic activities of LC in mice, male mice were used in the experiment and divided into four groups, each with seven animals. LC was administered intraperitoneally, and lipoperoxidation (LPO) was evaluated using the TBARS method. Antioxidant activity was evaluated using the enzymes superoxide dismutase and catalase. With lower doses of L-carnitine, there were increases in SOD and CAT, and at higher doses, a decrease in these same enzymes was observed, suggesting lipid peroxidation based on the TBARS test results. LC at all doses used in the comet assay in blood and liver showed no genotoxic activity; on the other hand, it reduced oxidative damage generated by hydrogen peroxide, suggesting antigenotoxic action. Therefore, this book is intended for biologists, geneticists, and anyone who uses the comet assay for analysis.

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Genetics

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