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Natürliche Verbindungen und Nanoformulierungen für Cisplatin-Nierenverletzungen
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ISBN10: 6208884934
ISBN13: 9786208884932
Publisher: Verlag Unser Wissen
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786208884932
Publisher: Verlag Unser Wissen
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: German
Die durch Cisplatin hervorgerufene akute Nierenschädigung stellt aufgrund ihrer multifaktoriellen Pathogenese, an der oxidativer Stress, Entzündung, Apoptose und Fibrose beteiligt sind, weiterhin eine gro e klinische Herausforderung dar. Es gibt immer mehr Belege für das nephroprotektive Potenzial von Naturstoffen wie Weizenkeimöl, Moringa oleifera, Ficus carica, Resveratrol, mehrfach ungesättigten Omega-3-Fettsäuren und Curcumin. Diese Wirkstoffe haben antioxidative, entzündungshemmende, antiapoptotische und antifibrotische Eigenschaften, die u. a. durch die Aktivierung des Nrf2-Signalwegs, die Hemmung von NF-κB und proinflammatorischen Zytokinen sowie die Erhaltung der Nierenarchitektur erreicht werden. Eine verbesserte Wirksamkeit wurde durch nanotechnologische Verabreichungssysteme - wie Nanoemulsionen, Goldnanopartikel und HA-beschichtete Träger - erreicht, die die Bioverfügbarkeit und die Ausrichtung auf die Nieren verbessern. Insgesamt bieten diese Naturstoffe, insbesondere in Nanoform, einen vielversprechenden, sicheren und zielgerichteten therapeutischen Ansatz zur Abschwächung der Cisplatin-induzierten AKI, ohne die Antitumorwirkung zu beeinträchtigen, was weitere klinische Untersuchungen rechtfertigt.
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