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Wirkung von Verapamil
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ISBN10: 6208497515
ISBN13: 9786208497514
Publisher: Verlag Unser Wissen
Published: Aug 30 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786208497514
Publisher: Verlag Unser Wissen
Published: Aug 30 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: German
Bei alkoholischer Hepatitis führt Leberfibrose zu einer Zirrhose und verursacht eine Leberzellfunktionsstörung, die ein Risikofaktor für Leberzellkarzinome ist. Diese Studie untersucht die potenzielle Toxizität von CCl4, ausgelöst durch Ethanol als hepatotoxische Substanz, auf die Glykogenstruktur der Leberzellen, den DNA-Gehalt und bestimmte Enzyme und bewertet au erdem die Wirkung eines bestimmten Calciumionenantagonisten wie Verapamil auf durch Tetrachlorkohlenstoff und Ethylalkohol verursachte Leberzellschäden bei Ratten. Die Lichtmikroskopie zeigte, dass Ratten, denen Ethanol und CCl4 zusammen verabreicht wurden, Leberzellfibrose und -nekrose, Kernfragmentierung und Entzündungsreaktionen aufwiesen. Au erdem wurden Glykogenstörungen und DNA-Schäden festgestellt. Bei Tieren, denen Verapamil verabreicht wurde, hingegen wurde eine Verringerung der Hepatozyten-Degeneration und -Nekrose sowie eine Verzögerung der Leberfibrosebildung festgestellt. Es gab eine deutliche Verbesserung der Hepatozytenarchitektur, des Glykogen- und DNA-Gehalts. Elektronenmikroskopische und biochemische Untersuchungen scheinen diese Ergebnisse zu bestätigen.
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