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Das Zusammenspiel zwischen Autophagie und Apoptose bei NSCLC
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ISBN10: 620249106X
ISBN13: 9786202491068
Publisher: Verlag Unser Wissen
Published: Jun 27 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786202491068
Publisher: Verlag Unser Wissen
Published: Jun 27 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: German
In dieser Studie wurde die Wirkung der Autophagiehemmung auf die apoptotische Reaktion in NSCLCs U1810-Zellen unter Nährstoffmangelbedingungen untersucht. Unter diesen Bedingungen wurde eine Induktion der Apoptose beobachtet, die von Caspase-8 abhängig war. Die Permeabilisierung der äu eren Mitochondrienmembran und die Aktivierung von Caspase-9 wurden nach der Caspase-8-Aktivität nachgewiesen, die auch für die Verringerung des langfristigen klonogenen Überlebens von Autophagie-defizienten Zellen essenziell war. Die Zugabe von Glutamin konnte diesen Effekt umkehren und den Zelltod von NSCLCs verhindern, während die Herunterregulierung der cFLIP-Spiegel einen Einfluss auf die Stimulierung der Caspase-8-Aktivierung hatte. Es wurde beobachtet, dass sich Caspase-8 in Aggregaten mit p62 anreichert, wo es aktiviert werden kann, was auf einen neuen intrinsischen Apoptosesignalweg hindeutet. Weitere Studien an Autophagie-defizienten Zellen sind erforderlich, um neue potenzielle Ziele für eine effiziente Eliminierung von Krebszellen zu identifizieren.
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