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The Golgi Apparatus and Centriole: Functions, Interactions and Role in Disease

The Golgi Apparatus and Centriole: Functions, Interactions and Role in Disease

Paperback

Series: Results and Problems in Cell Differentiation, Book 67

Medical ReferenceBiology

ISBN10: 3030231755
ISBN13: 9783030231750
Publisher: Springer Nature
Published: Sep 4 2020
Pages: 529
Weight: 1.68
Height: 1.12 Width: 6.14 Depth: 9.21
Language: English

This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined.

Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi-Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, variouslipid disorders and neurological and immunological diseases in humans.

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