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Studi strutturali sulla chinasi del linfoma anaplastico
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ISBN10: 6200686904
ISBN13: 9786200686909
Publisher: Edizioni Sapienza
Published: Sep 16 2025
Pages: 188
Weight: 0.57
Height: 0.43 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786200686909
Publisher: Edizioni Sapienza
Published: Sep 16 2025
Pages: 188
Weight: 0.57
Height: 0.43 Width: 6.00 Depth: 9.00
Language: Italian
La tirosin-chinasi ALK è espressa, come proteina di fusione NMP/ALK, in circa il 60% dei casi di linfoma anaplastico a grandi cellule (ALCL) e in altri tumori come il carcinoma polmonare non a piccole cellule (NSCLC) e il neuroblastoma. L'attivazione costitutiva del dominio chinasi ALK è responsabile della trasformazione maligna. La caratterizzazione strutturale del dominio chinasi ALK e le informazioni sulle interazioni farmaco-proteina potrebbero essere molto utili nella progettazione razionale di nuovi farmaci specifici per il trattamento dell'ALCL ALK+ e di altri tumori ALK+. Questo lavoro si è concentrato sulla produzione e la purificazione di diverse forme del dominio chinasi ALK per ottenere buoni candidati per studi strutturali ALK mediante cristallografia a raggi X e STD-NMR. La migliore forma di proteina ricombinante è stata utilizzata per selezionare potenziali inibitori ALK e per dimostrare l'interazione tra il dominio chinasi ALK e un nuovo inibitore della chinasi. I risultati di questo lavoro potrebbero aprire la strada allo sviluppo di nuovi farmaci specifici per il trattamento delle malattie ALK+. Questo lavoro potrebbe fornire un modello metodologico per la produzione e la purificazione di proteine ricombinanti e per i prossimi studi sull'interazione farmaco-proteina.
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