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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Neuromyelitis optica spectrum disorders and the HLA system

Neuromyelitis optica spectrum disorders and the HLA system

Mejdoub, Sabrina
Charfi, Aida
Feki, Sawsan

Paperback

Biology

ISBN10: 620898808X
ISBN13: 9786208988081
Publisher: Our Knowledge Publishing
Published: Jun 22 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: English
Neuromyelitis optica spectrum disorders (NMOSD) are a rare group of inflammatory demyelinating diseases of the central nervous system whose etiopathogenesis involves genetic factors. The association between HLA and NMOSD has been studied in various populations. However, no association study has been conducted in Tunisia.We therefore conducted a case-control study including 12 NMOSD patients (recruited over a period of 11 years) and 123 unrelated healthy subjects from the South Tunisian population. HLA class I typing was performed using the complement-dependent lymphocytotoxicity technique. HLA class II typing was performed by PCR-SSP. HLA marker polymorphism in our patients was statistically compared with the control group. For the HLA class I region, our work suggests the previously undescribed association of two markers with NMOSD: HLA-A23 and HLA-B7. For the HLA class II region, no association was found, contrary to studies carried out in other populations.Our results call for multicenter collaboration to expand our sample size and validate the HLA associations observed.

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