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Genotyp p53 kodon 72 Pro koreluje z agresywnym neuroblastomą
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ISBN10: 6208985676
ISBN13: 9786208985677
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 23 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786208985677
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 23 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Polish
Polimorfizm p53 w kodonie 72 wydaje się modulowac aktywnośc proapoptotyczną bialka i może miec negatywny wplyw na ryzyko zachorowania na raka oraz wyniki leczenia. W niniejszym badaniu oceniono częstośc występowania różnych genotypów p53 w grupie pacjentów z nerwiakiem niedojrzalym: pacjenci z genotypem Pro/Pro wydają się miec znacznie krótszy czas przeżycia calkowitego w porównaniu z pacjentami z genotypem Arg/Pro lub Arg/Arg. Sugeruje to, że genotyp Pro/Pro może identyfikowac podgrupę pacjentów z nerwiakiem niedojrzalym o agresywnym przebiegu choroby. Aby ocenic wplyw aktywacji p53 po chemioterapii lub radioterapii, utworzono pochodne linie komórkowe wyrażające indukowalną formę p53. Stwierdzono, że częstotliwośc komórek apoptotycznych z genotypem Arg/Arg byla wyższa niż w przypadku genotypu Pro/Pro. Chociaż istnieją wysoce skuteczne terapie dla pacjentów z neuroblastomami o niskim lub średnim ryzyku, nawroty choroby u pacjentów z wysokim ryzykiem pozostają wyzwaniem. Dlatego też niniejsze badanie może byc przydatne do pelniejszej charakterystyki genetycznej neuroblastomów w momencie rozpoznania oraz do poprawy stratyfikacji ryzyka, a byc może także odpowiedzi na leczenie u pacjentów.
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