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Zwapnienie ludzkich komórek śródblonka
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ISBN10: 620966606X
ISBN13: 9786209666063
Publisher: Wydawnictwo Nasza Wiedza
Published: Feb 17 2026
Pages: 104
Weight: 0.33
Height: 0.25 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209666063
Publisher: Wydawnictwo Nasza Wiedza
Published: Feb 17 2026
Pages: 104
Weight: 0.33
Height: 0.25 Width: 6.00 Depth: 9.00
Language: Polish
W jaki sposób komórki śródblonka tracą swoją tożsamośc i dlaczego rozpoczyna się proces zwapnienia? Zwapnienie naczyń krwionośnych jest cichym, ale niebezpiecznym procesem, który powoduje sztywnienie tętnic i przyspiesza rozwój chorób sercowo-naczyniowych. Badania eksperymentalne wykazaly, że zwapnienie nie jest bierną konsekwencją starzenia się, ale aktywnie regulowaną reakcją wywolaną plastycznością komórek śródblonka i otaczającym je mikrośrodowiskiem. Wykorzystując hodowle ludzkich komórek śródblonka, w niniejszej pracy zbadano, w jaki sposób komórki śródblonka przechodzą transformację śródblonkowo-mezenchymalną, przyjmują cechy osteogeniczne i inicjują odkladanie się wapnia. Opracowano zaawansowane dwu- i trójwymiarowe modele in vitro - w tym systemy wspólhodowli i samodzielnie zaprojektowane platformy stymulacji mechanicznej - w celu naśladowania kluczowych warunków naczyniowych bez konieczności przeprowadzania badań na zwierzętach lub pacjentach. Poprzez kontrolowaną manipulację sygnalami zapalnymi, sygnalizacją BMP, poziomami tlenu i silami mechanicznymi, niniejsza praca pokazuje, w jaki sposób określone sygnaly molekularne i fizyczne sprzyjają lub hamują zwapnienie. Analizy oparte na obrazowaniu ilościowym pokazują, że komunikacja międzykomórkowa, trójwymiarowa organizacja i bodźce biomechaniczne mają kluczowy wplyw na losy komórek śródblonka.
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