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Calcificação de células endoteliais humanas
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ISBN10: 6209668623
ISBN13: 9786209668623
Publisher: Edicoes Nosso Conhecimento
Published: Feb 17 2026
Pages: 104
Weight: 0.33
Height: 0.25 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209668623
Publisher: Edicoes Nosso Conhecimento
Published: Feb 17 2026
Pages: 104
Weight: 0.33
Height: 0.25 Width: 6.00 Depth: 9.00
Language: Portuguese
Como as células endoteliais perdem a sua identidade - e por que começa a calcificação? A calcificação vascular é um processo silencioso, mas perigoso, que endurece as artérias e acelera as doenças cardiovasculares. Em vez de ser uma consequência passiva do envelhecimento, este estudo experimental revela a calcificação como uma resposta ativamente regulada, impulsionada pela plasticidade das células endoteliais e pelo microambiente circundante. Utilizando culturas de células endoteliais humanas, este trabalho investiga como as células endoteliais passam por uma transição endotelial para mesenquimal, adotam caracterÃsticas osteogénicas e iniciam a deposição de cálcio. Modelos in vitro bidimensionais e tridimensionais avançados - incluindo sistemas de cocultura e plataformas de estimulação mecânica auto-projetadas - foram desenvolvidos para imitar condições vasculares importantes sem o uso de estudos em animais ou pacientes. Através da manipulação controlada de sinais inflamatórios, sinalização BMP, nÃveis de oxigénio e forças mecânicas, esta tese demonstra como sinais moleculares e fÃsicos especÃficos promovem ou suprimem a calcificação. Análises quantitativas baseadas em imagens revelam que a comunicação célula-célula, a organização tridimensional e os estÃmulos biomecânicos moldam criticamente o destino endotelial.
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