Sign-In
Cart
Abordagens estruturais para terapia direcionada
Paperback
Please select the version of book you would like to purchase.
ISBN10: 620783934X
ISBN13: 9786207839346
Publisher: Edicoes Nosso Conhecimento
Published: May 27 2025
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786207839346
Publisher: Edicoes Nosso Conhecimento
Published: May 27 2025
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: Portuguese
Os antÃgenos carboidratos associados a tumores (TACAs) são uma classe de glicanos com importantes funções estruturais e de sinalização que desempenham um papel importante na proliferação celular, diferenciação e apoptose relevantes para a oncologia. Abordagens baseadas na estrutura têm sido utilizadas para estudar as interações antÃgeno-anticorpo no microambiente tumoral, e também foi projetado um ligante peptÃdico que imita a topologia molecular dos TACAs, embora sejam estruturas moleculares quimicamente diferentes, mas funcionalmente equivalentes. Este trabalho sobre as interações anticorpo-TACA sugere que, ao projetar anticorpos, deve-se considerar cuidadosamente o uso de mutações que aumentam a rigidez de um anticorpo. Este trabalho também sugere que a eletrostática desempenha um papel importante no reconhecimento do antÃgeno modelo examinado. A discriminação contra alvos desejados por meio de interações eletrostáticas repulsivas pode ser mais proveitosa do que uma forte otimização da ligação ao alvo. O aumento da especificidade em relação a um alvo leva à diminuição da afinidade com outros.
Also from
Saha, Somdutta
Also in
Biology
The Age of Living Machines: How Biology Will Build the Next Technology Revolution
Hockfield, Susan
Paperback
$17.05
Entangled Life: How Fungi Make Our Worlds, Change Our Minds & Shape Our Futures
Sheldrake, Merlin
Paperback
From $11.99
Hidden Creatures: Luscious Leeches, Bashful Botflies, and the Wondrous, History-Shaping World of Parasites
Martins, Dino
Hardcover
$27.00
Beyond Inheritance: Our Ever-Mutating Cells and a New Understanding of Health
Khamsi, Roxanne
Hardcover
$28.50
The World Beneath Our Feet: The Hidden Life of Soil and Why It Matters to Us All
Ashwood, Frank
Hardcover
$28.50
History by a Hair: Thomas Jefferson, Sally Hemings & Solving a 200-Year-Old Mystery
Kurin, Richard
Hardcover
$31.50
The Biology of Trauma: How the Body Holds Fear, Pain, and Overwhelm, and How to Heal It
Apigian, Aimie
Hardcover
$26.96
Togetherness: Symbiosis and the Hidden Story of Life's Greatest Collaborations
Hooper, Rowan
Hardcover
$31.50
Go Forth and Forage: A Guide to Foraging Over 50 of the Most Common Edible & Medicinal North American Mushrooms
Johnson, Whitney
Paperback
$23.74
The Power of Life: The Invention of Biology and the Revolutionary Science of Jean-Baptiste Lamarck
Riskin, Jessica
Hardcover
$30.40
Ernst Haeckel's Art Forms in Nature: A Visual Masterpiece of the Natural World
Haeckel, Ernst
Hardcover
$48.74
Forbidden Facts: Government Deceit & Suppression about Brain Damage from Childhood Vaccines
de Becker, Gavin
Hardcover
$31.34
Fungi Decoded: Adventures in the Mycosphere--Encounters with Thirty Fungi
Bunyard, Britt A.
Paperback
$17.99
The Whole Truth: The Hidden Agendas Behind Decades of Health Misinformation--And What to Do about It
Campbell, T. Colin
Campbell, Nelson
Hardcover
$26.55
Princeton Review AP Biology Premium Prep, 29th Edition: 6 Practice Tests + Digital Practice Online + Content Review
The Princeton Review
Paperback
$26.59
Night Magic: Adventures Among Glowworms, Moon Gardens, and Other Marvels of the Dark
Henion, Leigh Ann
Hardcover
$28.50
Food Intelligence: The Science of How Food Both Nourishes and Harms Us
Belluz, Julia
Hall, Kevin, PhD
Hardcover
$28.50
Cells at Work! Picture Book 1: The Great Bacteria vs. White Blood Cell Battle!
Makimura, Kumi
Hardcover
$13.29
Peterson Field Guide to Mushrooms of North America, Second Edition
McKnight, Karl B.
Rohrer, Joseph R.
McKnight Ward, Kirsten
Paperback
$24.69
Bioinspired: How Nature Made Us Modern, Drives Today's Technological Innovation, and Inspires a Future Worth Inventing
Stier, Samuel Cord
Hardcover
$33.25
The Big One: How We Must Prepare for Future Deadly Pandemics
Olshaker, Mark
Osterholm, Michael T.
Hardcover
$27.00
A Year with the Seals: Unlocking the Secrets of the Sea's Most Charismatic and Controversial Creatures
Morris, Alix
Hardcover
$28.50
All That Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes
Black, Sue
Paperback
$18.04
VAX Facts: What to Consider Before Vaccinating at All Ages & Stages of Life
Thomas, Paul
Hoover, Deedee
Paperback
$25.60
Psilocybin: Magic Mushroom Grower's Guide: A Handbook for Psilocybin Enthusiasts
Oeric, O. N.
Oss, O. T.
Paperback
$18.00
The Gut-Brain Paradox: Improve Your Mood, Clear Brain Fog, and Reverse Disease by Healing Your Microbiome
Gundry MD, Steven R.
Hardcover
$30.40
The Aesthetic Revolution: Embracing Vanity and the Future of Fitness to Unlock Your Healthiest Self
Israetel, Mike
Hardcover
$28.50
True Hallucinations: Being an Account of the Author's Extraordinary Adventures in the Devil's Paradis
McKenna, Terence
Paperback
$17.09
National Geographic the Photo Ark: One Man's Quest to Document the World's Animals
Sartore, Joel
Chadwick, Douglas H.
Hardcover
From $19.99
Psilocybin Mushrooms: A Comprehensive Guide to Growing and Using Psychedelic Mushrooms
Madden, Michael
Paperback
$14.24
Fungi of Temperate Europe: Keys to the Basidiomycotes
Læssøe, Thomas
Petersen, Jens H.
Frøslev, Tobias G.
Hardcover
$90.25
Mushrooms of the Redwood Coast: A Comprehensive Guide to the Fungi of Coastal Northern California
Siegel, Noah
Schwarz, Christian
Paperback
$33.25
Entangled Life: How Fungi Make Our Worlds, Change Our Minds & Shape Our Futures
Sheldrake, Merlin
Hardcover
$28.50
The Little Book of Mushrooms: An Illustrated Guide to the Extraordinary Power of Mushrooms
Dorr, Alex
Hardcover
From $11.99
The Life Machines: How Taking Care of Your Mitochondria Can Transform Your Health
Mochly-Rosen, Daria
Rosen, Emanuel
Hardcover
$27.55
Mushrooming: An Illustrated Guide to the Fantastic, Delicious, Deadly, and Strange World of Fungi
Borsato, Diane
Hardcover
$23.70
The Contagion Myth: Why Viruses (Including Coronavirus) Are Not the Cause of Disease
Cowan, Thomas S.
Fallon Morell, Sally
Hardcover
$31.34
From These Lands: Sharing Our Natural and Cultural Heritage
National Museum of Natural History
Hardcover
$18.95
How to Win Friends and Influence Fungi: Collected Quirks of Science, Tech, Engineering, and Math from Nerd Nite
Balakrishnan, Chris
Wasowski, Matt
Paperback
$19.00
Human Errors: A Panorama of Our Glitches, from Pointless Bones to Broken Genes
Lents, Nathan H.
Paperback
$17.09
Pull: How Gravity Shapes Your Body, Steadies the Mind, and Guides Our Health
Spiegel, Brennan
Hardcover
$28.50
The Ocean's Menagerie: How Earth's Strangest Creatures Reshape the Rules of Life
Harvell, Drew
Hardcover
$28.80
Mushrooms of Cascadia, Second Edition: An Illustrated Key to the Fungi of the Pacific Northwest
Beug, Michael
Paperback
$26.60
The Mycocultural Revolution: Transforming Our World with Mushrooms, Lichens, and Other Fungi
McCoy, Peter
Hardcover
$17.05
The Art and Science of Foodpairing: 10,000 Flavour Matches That Will Transform the Way You Eat
Lahousse, Bernard
Langenbick, Johan
Coucquyt, Peter
Hardcover
$47.45
The Pale Blue Data Point: An Earth-Based Perspective on the Search for Alien Life
Willis, Jon
Hardcover
$24.70
Field Notes from a Fungi Forager: An Illustrated Journey Through the World of Pacific Northwest Mushrooms
Rodriguez, Ashley
Hardcover
$21.80
Gut Check: Unleash the Power of Your Microbiome to Reverse Disease and Transform Your Mental, Physical, and Emotional Health
Gundry MD, Steven R.
Hardcover
$30.40
National Audubon Society Wildflowers of North America: The Complete Identification Reference to Wildflowers--With Full-Color Photographs; Updated Rang
National Audubon Society
Hardcover
$37.95
Life in Sync: The Science of Internal Clocks and How We're Disrupting Them
Gander, Philippa
Hardcover
$21.80
The Serengeti Rules: The Quest to Discover How Life Works and Why It Matters
Carroll, Sean B.
Paperback
$18.00
The Hidden Half of Nature: The Microbial Roots of Life and Health
Biklé, Anne
Montgomery, David R.
Paperback
From $10.99
Field Guide to Wild Mushrooms of Pennsylvania and the Mid-Atlantic: Revised and Expanded Edition
Russell, Bill
Paperback
$23.70
The Double Helix: A Personal Account of the Discovery of the Structure of DNA
Watson, James D.
Paperback
$18.99
Sea Wonders: The Octopus, the Cuttlefish, and the Squid
Colombo, Marco
Tomasinelli, Francesco
Hardcover
$18.95
Superconvergence: How the Genetics, Biotech, and AI Revolutions Will Transform Our Lives, Work, and World
Metzl, Jamie
Paperback
$20.89