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Efeitos de baixa dose de Bisfenol A em células humanas primárias e cancerÃgenas
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ISBN10: 6208358353
ISBN13: 9786208358358
Publisher: Edicoes Nosso Conhecimento
Published: Dec 6 2024
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208358358
Publisher: Edicoes Nosso Conhecimento
Published: Dec 6 2024
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Portuguese
O bisfenol A (BPA), 2,2-bis(4-hidroxifenil) propano, é um composto orgânico e um dos produtos quÃmicos industriais de maior volume produzidos em todo o mundo. A exposição humana ao BPA, na gama das chamadas doses baixas, é considerada um fenómeno generalizado, particularmente através da ingestão oral. Estudos de biomonitorização revelam a presença de BPA na maioria dos indivÃduos dos paÃses desenvolvidos. O BPA é um desregulador endócrino bem caracterizado que pode provocar respostas celulares muito distintas através de várias vias de sinalização do recetor de estrogénio frequentemente associadas a especificidades do tipo de célula. Uma extensa investigação em linhas celulares humanas de tecidos sensÃveis à s hormonas sexuais demonstrou os potenciais efeitos nocivos da exposição ao BPA, incluindo a carcinogénese. No entanto, embora o BPA seja absorvido no intestino e entre na circulação sanguÃnea, os seus efeitos nas células dos sistemas digestivo e vascular são largamente desconhecidos. É urgente dar resposta à s crescentes preocupações relativas aos potenciais efeitos adversos da exposição a baixas doses de BPA e avaliar as potenciais interações no contexto da avaliação dos riscos para a saúde humana.
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