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Espondilite anquilosante
Paperback
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ISBN10: 6209590659
ISBN13: 9786209590658
Publisher: Edicoes Nosso Conhecimento
Published: Jan 16 2026
Pages: 108
Weight: 0.34
Height: 0.26 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209590658
Publisher: Edicoes Nosso Conhecimento
Published: Jan 16 2026
Pages: 108
Weight: 0.34
Height: 0.26 Width: 6.00 Depth: 9.00
Language: Portuguese
A espondilite anquilosante (EA) é uma doença reumática autoimune crónica que afecta as articulações da coluna vertebral e os tecidos moles adjacentes. Ocorre em pessoas jovens e é predominantemente masculina. Suspeita-se da existência de factores genéticos e ambientais na génese da doença, em particular a vitamina D, o seu recetor (VDR) e o HLAB27.O curso clÃnico e o prognóstico dependem da idade de inÃcio, sendo o inÃcio tardio caracterizado por um aumento acentuado dos parâmetros biológicos e doença grave, em comparação com o inÃcio precoce.As diferenças de género nas manifestações clÃnicas podem ser atribuÃdas a combinações variáveis de determinados haplótipos genéticos. Além disso, os doentes apresentam frequentemente manifestações extra-articulares (EAM), que são elementos importantes para um diagnóstico adequado. Estas incluem a uveÃte, a doença inflamatória intestinal crónica (DII), onde está presente em cerca de 2-9% dos casos, e a psorÃase.
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