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PPAR-beta/delta: nuovo bersaglio nel trattamento della sindrome metabolica
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ISBN10: 6209492282
ISBN13: 9786209492280
Publisher: Edizioni Sapienza
Published: Jan 6 2026
Pages: 112
Weight: 0.35
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786209492280
Publisher: Edizioni Sapienza
Published: Jan 6 2026
Pages: 112
Weight: 0.35
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Italian
La sovrattivazione dell'asse ECA/AT1r è strettamente correlata alla sindrome metabolica e all'infiammazione. La somministrazione di fruttosio è stata utilizzata come modello per indurre la sovrattivazione di questo asse e per studiare le vie infiammatorie correlate all'AT1r. Lo scopo del lavoro era valutare se la somministrazione di un agonista PPAR-beta/delta potesse ridurre la sovrattivazione dell'asse ECA/AT1r e, di conseguenza, diminuire i danni causati da una dieta ricca di fruttosio. A tal fine sono stati utilizzati topi maschi che hanno ricevuto una dieta contenente il 47% di fruttosio per otto settimane o una dieta di controllo. Dopo otto settimane, i gruppi sono stati ridivisi per l'inizio della somministrazione dell'agonista per tre settimane. Gli animali trattati hanno mostrato diversi miglioramenti nei parametri metabolici e infiammatori valutati nel fegato, nel tessuto adiposo bianco e nei reni. Con questi risultati possiamo concludere che la breve somministrazione di GW501516 ha potuto alleviare gli effetti deleteri causati dalla dieta ricca di fruttosio, e può essere considerata un nuovo strumento terapeutico nel trattamento della sovrattivazione dell'asse ECA/AT1r.
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