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O poder neuroprotector do Tribulus
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ISBN10: 6207660625
ISBN13: 9786207660629
Publisher: Edicoes Nosso Conhecimento
Published: Jun 13 2024
Pages: 88
Weight: 0.31
Height: 0.21 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786207660629
Publisher: Edicoes Nosso Conhecimento
Published: Jun 13 2024
Pages: 88
Weight: 0.31
Height: 0.21 Width: 6.00 Depth: 9.00
Language: Portuguese
Recentemente, o Tribulus terrestris (Tt) tem atraÃdo um interesse crescente devido ao seu potencial farmacológico, incluindo as suas actividades neuroprotectoras. Neste estudo, exploramos os efeitos neuroprotectores de um extrato de Tt num modelo de peixe-zebra (Danio rerio) de perturbação da memória induzida por escopolamina (SCOP) e stress oxidativo cerebral. A SCOP, um fármaco anticolinérgico, tem sido utilizada para reproduzir aspectos fundamentais da doença de Alzheimer (DA) em modelos animais. Os peixes foram tratados com extrato etanólico de folhas (ELE) de Tt (1, 3 e 6 mg/L) durante 15 dias. As interacções moleculares dos principais compostos identificados através de UPLC-PDA/MS nas fracções de Tt com o local ativo da acetilcolinesterase (AChE) foram exploradas através de análises de docagem molecular. A terrestrosina C, a protodioscina, a rutina e a saponina C apresentaram a ligação mais estável. O desempenho da memória espacial foi avaliado utilizando o teste do labirinto em Y e o reconhecimento da memória foi avaliado utilizando o teste NOR.
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