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Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer

Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer

Paperback

Business General

ISBN10: 6209363520
ISBN13: 9786209363528
Publisher: LAP Lambert Academic Publishing
Published: Dec 12 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: English
This study explores the expression of Yes-associated protein (YAP), a key effector of the Hippo pathway, across the spectrum of oral carcinogenesis. Using immunohistochemistry on ethically sourced samples of normal oral mucosa, leukoplakia, and oral squamous cell carcinoma (OSCC), we observed a clear, progressive rise in YAP staining from healthy tissue to dysplasia and finally to OSCC. Dysplastic lesions showed stepwise increases in YAP intensity correlating with severity, while OSCC displayed the highest expression. Both nuclear and cytoplasmic staining were evident, with nuclear positivity (>10%) highlighting YAP's active transcriptional role in promoting cell growth and malignant transformation. These findings suggest that YAP is a significant biomarker and potential driver of oral cancer progression.

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Nandhakumar, Indumathi

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Business General