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Adrenomyeloneuropathy: Spinal Cord Disorders: Symptoms, Diagnosis, Prevention and Treatment
Paperback
Publisher: Independently Published
Published: Oct 18 2021
Pages: 28
Weight: 0.08
Height: 0.06 Width: 5.00 Depth: 8.00
Language: English
If the responsible gene is found on the X chromosome, one of the two sex chromosomes, the condition is considered X-linked. One of the two chromosomes found in males and females is known as the Y chromosome. Both sexes have an X chromosome and a Y chromosome, with women possessing two X chromosomes.
Because men only have one copy of the X chromosome, a single mutated copy of the disease-causing gene is all that's needed to manifest symptoms. All of a man's daughters will be affected by an X-linked condition, but none of his sons will be. The normal copy of the gene on the other X chromosome may mask the effect of the mutant on women's X chromosome because they have two X chromosomes. Women who only have one mutation are referred to as carriers.
Women who carry the virus typically show no signs of illness or only experience minor symptoms.
Some women, however, may be just as badly affected as men by the disease. X-linked conditions are 50% more likely to be passed down to future generations if a woman is pregnant while carrying the condition herself. About 20% of women with one AMN ABCD1 mutation develop stiffness and weakness in their legs later in life, usually in their forties or fifties. Adrenal function is usually normal in these women.
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