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Cancer Hypoxia: Implication in Therapeutics and Precision Oncology

Cancer Hypoxia: Implication in Therapeutics and Precision Oncology

Hardcover

Medical Reference

ISBN10: 1032761806
ISBN13: 9781032761800
Publisher: CRC Press
Published: Mar 12 2026
Pages: 216
Weight: 1.35
Height: 0.56 Width: 7.00 Depth: 10.00
Language: English

This book comprehensively reviews the role of hypoxia in cancer initiation and progression. It explores hypoxia-driven signaling pathways and the immune microenvironment in hypoxic tumors, offering insights into network implications for cancer development and therapy, along with strategies to counter hypoxia-induced immune suppression. Investigating influence of hypoxia on cancer stem cells and cellular stemness, the book highlights its role in maintaining stemness at hypoxic niches and potential therapeutic opportunities. The book, in turn, explores tools and techniques for the detection of hypoxic phenotypes and in vivo models for studying hypoxic cancer, angiogenesis, and vasculature remodeling in hypoxic tumors, discussing innovative drug delivery, and targeting hypoxia-inducible factors. Finally, it outlines clinical applications of hypoxia research in cancer therapy, ranging from advancements in radiation strategies to biomarkers, diagnosis, precision medicine, and future directions in hypoxia-activated prodrug research. This comprehensive resource serves as a valuable reference for researchers, clinicians, and professionals engaged in understanding and combating cancer hypoxia.

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Mukherjee, Sukhes

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Medical Reference