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    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
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Current Topics in Microbiology and Immunology: Ergebnisse Der Mikrobiologie Und Immunitätsforschung Volume 59

Current Topics in Microbiology and Immunology: Ergebnisse Der Mikrobiologie Und Immunitätsforschung Volume 59

Haas, R.
Arber, W.
Braun, W.

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 59

Medical ReferenceBiology

ISBN10: 3642654460
ISBN13: 9783642654466
Publisher: Springer Pg
Published: Nov 15 2011
Pages: 258
Weight: 0.94
Height: 0.55 Width: 6.69 Depth: 9.61
Language: English
Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan- ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula- tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN- CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem- agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.

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