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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Donnadieu, Emmanuel

Hardcover

Series: Resistance to Targeted Anti-Cancer Therapeutics, Book 9

Medical ReferenceBiology

ISBN10: 3319422219
ISBN13: 9783319422213
Publisher: Springer Nature
Published: Sep 6 2016
Pages: 199
Weight: 1.03
Height: 0.50 Width: 6.14 Depth: 9.21
Language: English
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

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