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The Blood-Brain Barrier: Methods and Protocols
Hardcover
Series: Methods in Molecular Biology, Book 2492
Medical ReferenceAnatomy & Physiology
ISBN13: 9781071622889
Publisher: Humana
Published: Jun 24 2022
Pages: 357
Weight: 1.90
Height: 0.88 Width: 7.00 Depth: 10.00
Language: English
Part I: Introduction to Blood-Brain Barrier (BBB) Physiology
1. Cells of the Blood-Brain Barrier: An Overview of the Neurovascular Unit in Health and Disease
Heather L. McConnell and Anusha Mishra
2. In Vitro Models of the Blood-Brain Barrier
Snehal Raut, Aditya Bhalerao, Behnam Noorani, and Luca Cucullo
Part II: Using Pluripotent Stem Cells in Models of the BBB
3. In Vitro Models of the Human Blood-Brain Barrier Based on Human Induced Pluripotent Stem Cells: Opportunities and Challenges
Iqra Pervaiz and Abraham J. Al-Ahmad
4. Induced Pluripotent Stem Cell (iPSC)-Derived Endothelial Cells to Study Bacterial-Brain Endothelial Cell Interactions
Eric R. Espinal, S. Jerod Sharp, and Brandon J. Kim
5. An hiPSC-Derived In Vitro Model of the Blood-Brain Barrier
Mary Goodwin-Trotman, Krushangi Patel, and Alessandra Granata
6. A Three-Dimensional Brain-on-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes
Lumei Liu, Youngmi Koo, Teal Russell, and Yeoheung Yun
Part III: Co-Culture, Permeability, and Transwell Models of the BBB: Methods for Studying Shear Stress, Barrier Integrity and Breakdown
7. An Improved In Vitro Porcine Blood-Brain Barrier Model for Permeability Screening and Functional Studies
Adjanie Patabendige
8. Establishment of an In Vitro Model of Human Blood-Brain Barrier to Study the Impact of Ischaemic Injury
Rais Reskiawan A. Kadir, Mansour Alwjwaj, and Ulvi Bayraktutan
9. A Novel Dynamic Human In Vitro Model for Studying the Blood-Brain Barrier
Patricia Miranda-Azpiazu and Sikha Saha
10. A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress
Gemma Molins Gutierrez, Jordi Martorell, Antonio G. Salazar-Martin, and Mercedes Balcells
Part IV: Microfluidic and Chip Models of the BBB
11. Novel, Emerging Chip Models of the BBB and Future Directions
Paul M. Holloway
12. Integrating Primary Astrocytes in a Microfluidic Model of the Blood-Brain Barrier
Eliana Lauranzano, Marco Rasile, and Michela Matteoli
13. Fabrication of Microtube-Embedded Chip to Mimic Blood-Brain Barrier Capillary Vessels
Dilshan Sooriyaarachchi, Shahrima Maharubin, and George Z. Tan
14. BBB-on-a-Chip: Modeling Functional Human BBB by Mimicking 3D Brain Angiogenesis Using Microfluidic Chip
Somin Lee, Minhwan Chung, and Noo Li Jeon
Part V: Models
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