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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Drug Metabolism and Pharmacokinetics

Drug Metabolism and Pharmacokinetics

Pignatello, Rosario
Rudrapal, Mithun

Hardcover

Series: Pharmaceutical Science, Book 2

Medical Reference

Currently unavailable to order

ISBN10: 0850141478
ISBN13: 9780850141474
Publisher: Intechopen
Published: Feb 14 2024
Pages: 136
Weight: 1.19
Height: 0.50 Width: 7.00 Depth: 10.00
Language: English
This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug-drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: - Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations - Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies - Summarizes in silico, in vitro, and in vivo methods used in drug-enzyme interactions, drug- drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.

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