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Effet toxique du phtalate sur le rat albinos et récupération par l'extrait de céleri
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ISBN10: 620776207X
ISBN13: 9786207762071
Publisher: Editions Notre Savoir
Published: Jul 6 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786207762071
Publisher: Editions Notre Savoir
Published: Jul 6 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: French
La toxicité aiguë du phtalate de di-(2 éthylhexyle) (DEHP) a été étudiée sur les enzymes hépatiques de rats albinos mâles adultes (Rattus norvegicus) et la récupération a été effectuée à l'aide d'un extrait de graines de céleri. Le phtalate de di-(2 éthylhexyle) (DEHP) est un plastifiant courant utilisé pour rendre les produits en plastique plus flexibles. Testé sur d'autres modèles animaux, il est assez nocif et également cancérigène. Le foie est le principal organe de désintoxication de l'organisme et il est donc le premier à être endommagé par l'ingestion de substances toxiques. Les enzymes hépatiques sont un bon paramètre pour évaluer toute atteinte hépatique. Le plastifiant DEHP a été administré par voie orale à un groupe de rats albinos mâles adultes et les enzymes hépatiques phosphatase alcaline, phosphatase acide, alanine transaminase, aspartate transaminase et lactate déshydrogénase ont été mesurées. Les recherches ont montré une diminution des niveaux d'ALP et d'ACP dans le sang, ainsi qu'une augmentation de l'ALT et de l'AST après le traitement. L'extrait de graines de céleri (Apium graveolens) a été administré aux rats traités pour leur permettre de se rétablir et les taux sanguins d'enzymes hépatiques sont revenus à la normale.
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