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Efeito tóxico do ftalato no rato albino e recuperação com extrato de aipo
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ISBN10: 6207762096
ISBN13: 9786207762095
Publisher: Edicoes Nosso Conhecimento
Published: Jul 6 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786207762095
Publisher: Edicoes Nosso Conhecimento
Published: Jul 6 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
A toxicidade aguda do ftalato de di-(2-etil-hexilo) (DEHP) foi estudada nas enzimas hepáticas de ratos albinos machos adultos (Rattus norvegicus) e a recuperação foi feita utilizando extrato de sementes de aipo. O ftalato de di-(2-etil-hexilo) (DEHP) é um plastificante comum utilizado para tornar os produtos de plástico mais flexÃveis. É bastante nocivo, conforme testado noutros modelos animais, e também é carcinogénico. O fÃgado é o principal órgão de desintoxicação do corpo e, por conseguinte, é o primeiro a ser danificado devido à ingestão de quaisquer substâncias tóxicas. As enzimas hepáticas são um bom parâmetro para avaliar qualquer dano hepático. O plastificante DEHP foi administrado por via oral a um grupo de ratos albinos machos adultos e foram medidas as enzimas hepáticas fosfatase alcalina, fosfatase ácida, alanina transaminase, aspartato transaminase e lactato desidrogenase. A investigação mostrou que houve uma diminuição dos nÃveis de ALP e ACP no sangue, enquanto houve um aumento de ALT e AST após o tratamento. O extrato de sementes de aipo (Apium graveolens) foi dado aos ratos tratados para recuperação e os nÃveis sanguÃneos das enzimas hepáticas voltaram ao normal.
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