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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Formulation Development and Characterization of Nanosuspension

Formulation Development and Characterization of Nanosuspension

Mohapatra, Dillip Kumar
Jivani, Rishad
Sahu, Asit Ranjan

Paperback

Medical Reference

ISBN10: 6200306567
ISBN13: 9786200306562
Publisher: Lap Lambert Academic Pub
Published: Sep 4 2019
Pages: 88
Weight: 0.31
Height: 0.21 Width: 6.00 Depth: 9.00
Language: English
This study was to identify and optimize formulation and process variables affecting characteristic and scale-up of nanosuspension manufacturing process on bead mill i.e media milling buttom down technique considering industrial perspective. Formulation factors evaluated were ratio of different polymer to drug and to beads. Whereas process parameters were milling bead concentration and stabilizer concentration. Responses measured in this study include zeta potential and mean particle size. The test revealed that ratio of polymer to drug have significant effect on zeta potential whereas variable milling bead concentration at constant milling speed and milling time have significant effect on the particle size distribution of nanosuspension. The X-ray powder diffraction pattern of drug milled at high and low speed reveals no form conversion when compared with unmilled drug. The formulated nanosuspension has shown a faster % cumulative release.

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