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G Protein-Coupled Receptor Kinases
Hardcover
Series: Methods in Pharmacology and Toxicology
ISBN13: 9781493937967
Publisher: Humana Pr
Published: Jul 21 2016
Pages: 329
Weight: 1.79
Height: 0.81 Width: 7.00 Depth: 10.00
Language: English
Part I: Introduction
1. G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery
Vsevolod V. Gurevich and Eugenia V. Gurevich
Part II: GRK Structure, Mechanisms of Activation, and Interaction with GPCRs
2. Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7
Tivadar Orban and Krzysztof Palczewski
3. Visual G Protein-Coupled Receptor Kinases
Chih-Chun Hsu and Ching-Kang Jason Chen
4. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily
Tyler S. Beyett, Sumit J. Bandekar, and John J.G. Tesmer
5. Barcode and Differential Effects of GPCR Phosphorylation by Different GRKs
Kunhong Xiao and Hongda Liu
Part III: GRKs in Cell Signaling
6. Cell-Type Specific GRK2 Interactomes: Physiopathological Implications
Federico Mayor, Jr., RocÃo Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas, Clara Reglero, Petronila Penela, and Cristina Murga
7. Differential Regulation of IGF-1 and Insulin Signaling by GRKs
Leonard Girnita, Ada Girnita, and Caitrin Crudden
8. Differential Control of Potassium Channel Activity by GRK2
Adi Raveh, Liora Guy-David, and Eitan Reuveny
Part IV: Physiological and Pathophysiological Mechanisms Regulated by GRKs
9. Critical Role of GRK2 in the Prevention of Chronic Pain
Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, and Annemieke Kavelaars
10. Roles of GRK Dysfunction in Alzheimer's Pathogenesis
William Z. Suo
11. Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases
Eugenia V. Gurevich, Raul R. Gainetdinov, and Vsevolod V. Gurevich
12. G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation
Alessandro Cannavo, Claudio de Lucia, and Walter J. Koch
13. GRK Roles in C. elegans
Jordan F. Wood and Denise M. Ferkey
14. Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway
Dominic Maier and David R. Hipfner
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