Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Platelet Alloantibody

Platelet Alloantibody

Mustafa, Rapiaah
Wan Mohd Zain, Wan Soriany
Wan Mahmood, Wan Haslindawani

Paperback

Medical Reference

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ISBN10: 3846505048
ISBN13: 9783846505045
Publisher: Lap Lambert Academic Pub
Published: Mar 27 2012
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: English
The frequency of platelet-specific antibodies in multitransfused patients and their implication in platelet transfusion refractoriness has been a matter of controversy for years. The main reasons are the difficulties encountered in differentiating between HLA- and platelet-specific antibodies and, within platelet-specific antibodies, between auto- or alloantibodies, using the available platelet antiglobulin test. In the recent years, capture assays were developed, using immobilized platelet membrane glycoprotein (GP) carrying the antigens under investigation to avoid using whole platelets. These assays overcome the difficulties in differentiating platelet-reactive antibody mixtures and allow determination of antibody specificity. For the group of highly HLA-immunized patients in need for HLA-matched single donor platelets, however, there are only as many as 25% will have additional platelet-specific alloantibodies. These platelet-specific alloantibodies will prohibit satisfactory transfusion results if HLA-matched but HPA-incompatible platelets are transfused.

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