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Espressione genica ATP6V1H nel diabete di tipo 2
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ISBN10: 6139669324
ISBN13: 9786139669325
Publisher: Edizioni Sapienza
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786139669325
Publisher: Edizioni Sapienza
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Italian
Lo scopo di questa ricerca era triplice: 1) studiare i parametri demografici e fisiologici di nove individui del CCHC che hanno sviluppato il diabete nel corso dei tre anni del periodo di studio; 2) indagare se il gene che codifica la subunità H della V-ATPasi (ATP6V1H) fosse sottoregolato nei nove individui durante la progressione dal pre-diabete al diabete di tipo 2; 3) eseguire un'ampia revisione della letteratura sul gene ATP6V1H e sul suo prodotto proteico, la subunità H della V-ATPasi, per ipotizzare quale ruolo potrebbe svolgere nello sviluppo del diabete e delle sue complicanze. Secondo l'Organizzazione Mondiale della Sanità , ci sono circa 346 milioni di casi di diabete in tutto il mondo, il 90% dei quali è attribuito specificamente al diabete di tipo 2. Poiché il diabete di tipo 2 continua a destare preoccupazione, i ricercatori stanno iniziando a concentrare la loro attenzione sui fattori intrinseci che predispongono gli individui alla malattia, uno dei quali è la genetica. Recentemente, è stata osservata una maggiore prevalenza di diabete di tipo 2 in una coorte di 2.500 membri di origine messicana-americana stabilitasi al confine tra Stati Uniti e Messico, in particolare a Brownsville (Contea di Cameron), in Texas.
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