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Ekspresja genu ATP6V1H w cukrzycy typu 2
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ISBN10: 6139600685
ISBN13: 9786139600687
Publisher: Wydawnictwo Nasza Wiedza
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786139600687
Publisher: Wydawnictwo Nasza Wiedza
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Polish
Celem niniejszego badania byly trzy kwestie: 1) zbadanie parametrów demograficznych i fizjologicznych dziewięciu osób z CCHC, u których w ciągu trzech lat trwania badania rozwinęla się cukrzyca; 2) zbadanie, czy gen kodujący podjednostkę H V-ATPazy (ATP6V1H) ulegl obniżonej ekspresji u dziewięciu osób w miarę postępu stanu przedcukrzycowego do cukrzycy typu 2; 3) przeprowadzenie obszernej analizy literatury dotyczącej genu ATP6V1H i jego produktu bialkowego, podjednostki H V-ATPazy, w celu sformulowania hipotezy dotyczącej roli, jaką może on odgrywac w rozwoju cukrzycy i jej powiklań. Wedlug Światowej Organizacji Zdrowia na calym świecie odnotowano okolo 346 milionów przypadków cukrzycy, z czego 90% przypisuje się cukrzycy typu 2. Ponieważ cukrzyca typu 2 nadal budzi niepokój, naukowcy zaczynają skupiac się na czynnikach predysponujących osoby do tej choroby, z których jednym jest genetyka. Niedawno zaobserwowano wyższą częstośc występowania cukrzycy typu 2 w grupie 2500 meksykańsko-amerykańskich mieszkańców zamieszkujących pogranicze amerykańsko-meksykańskie, a konkretnie w Brownsville (hrabstwo Cameron) w Teksasie.
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