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Recenti progressi negli approcci bioanalitici per la scoperta di biomarcatori
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ISBN10: 6200749167
ISBN13: 9786200749161
Publisher: Edizioni Sapienza
Published: Jul 23 2025
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786200749161
Publisher: Edizioni Sapienza
Published: Jul 23 2025
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: Italian
Le infezioni da schistosomi hanno gravi implicazioni per lo sviluppo socioeconomico in molti paesi tropicali. Queste malattie debilitanti e croniche sono endemiche in oltre 70 paesi, ma gli strumenti diagnostici sono limitati e sono necessari nuovi test per limitare la morbilità e la mortalità . Lo sviluppo di tali test potrebbe essere facilitato dall'identificazione di biomarcatori specifici della malattia che siano positivi nelle prime fasi dell'infezione, in grado di distinguere tra infezione acuta e cronica e che possano servire come conferma della guarigione. Questo lavoro ha due obiettivi principali: (a) identificare i modelli proteomici specifici per stadio durante l'infezione da Schistosoma mansoni in fase iniziale (3 settimane), acuta (6 settimane) e cronica (12 settimane) in un modello murino; (b) profilare il siero di esseri umani infetti da S. mansoni o S. haematobium e confrontare questi modelli con il profilo proteico del siero umano sano. Per raggiungere questi obiettivi, sono state eseguite analisi proteomiche su sieri di topi e umani utilizzando diverse metodologie di spettrometria di massa (MS).
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